Arch Intern Med
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Randomized Controlled Trial
Nonsurgical weight loss for extreme obesity in primary care settings: results of the Louisiana Obese Subjects Study.
Effective primary care practice (PCP) treatments are needed for extreme obesity. The Louisiana Obese Subjects Study (LOSS) tested whether, with brief training, PCPs could effectively implement weight loss for individuals with a body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) of 40 to 60. ⋯ Primary care practices can initiate effective medical management for extreme obesity; future efforts must target improving retention and weight loss maintenance.
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Randomized Controlled Trial
Resistance training and executive functions: a 12-month randomized controlled trial.
Cognitive decline among seniors is a pressing health care issue. Specific exercise training may combat cognitive decline. We compared the effect of once-weekly and twice-weekly resistance training with that of twice-weekly balance and tone exercise training on the performance of executive cognitive functions in senior women. ⋯ Twelve months of once-weekly or twice-weekly resistance training benefited the executive cognitive function of selective attention and conflict resolution among senior women.
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Multicenter Study
Improving prescription drug warnings to promote patient comprehension.
Prior studies have documented a high prevalence of patients who misunderstand prescription drug warning labels, placing them at risk for medication error. We evaluated whether the use of "enhanced print" drug warnings could improve patient comprehension beyond a current standard. ⋯ Simple, explicit language on warning labels can increase patient understanding; the addition of appropriate icons is particularly useful for adults with lower literacy skills. Evidence-based standards are needed to promote patient-centered prescription labeling practices.
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Adverse effects of combination antiretroviral therapy (CART) commonly result in treatment modification and poor adherence. ⋯ Drug toxicity remains a frequent reason for treatment modification; however, it does not affect treatment success. Close monitoring and management of adverse effects and drug-drug interactions are crucial for the durability of CART.