Arch Iran Med
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The genetic generalized epilepsies (GGEs) are a set of disorders presenting with generalized seizures, in addition to general spike-wave activity. The present study aims to investigate the clinical manifestations and genetic origin of generalized tonicclonic seizures and the subgroups of GGEs, including childhood absence epilepsy (CAE), juvenile absence epilepsy, and juvenile myoclonic epilepsy (JME). Information compiled from genome-wide association studies (GWASs) in the EPICure project revealed associations with many genes. ⋯ Nowadays, next-generation sequencing (NGS) approaches support neurogeneticists to unravel the predisposed putative variants in GGE to establish a better diagnosis. Consequently, previous experiments supply data for antiepileptic drugs (AEDs) to test susceptible variants, which influence the response to drugs. As a final point, all these data should provide the current GGE patients with better genetic counseling and follow-up services.
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Weight disorders in childhood are considered as a global health problem with several adverse health effects. The objective of this study is to review available studies on the prevalence of overweight, obesity and underweight in Iranian pediatric population. ⋯ Similar to many other developing countries, double burden of nutritional disorders exists in children living in some parts of Iran. While till now most health policies and educational programs related to children's nutrition in Iran had focused on underweight and malnutrition, more attention should be paid to the problem of excess weight.