Arch Iran Med
-
Comb homolog enhancer 1 (EPC1) gene is one of the important members of epigenetic inhibitor PCG family. It shows carcinogenic potential in a variety of malignant tumors, but the expression and role of EPC1 in nasopharyngeal carcinoma are unclear. The aim of this study was to explore the expression and function of enhancer of polycomb homolog 1 (EPC1) in nasopharyngeal carcinoma (NPC). ⋯ EPC1 expression was upregulated in NPC tissues and cell lines. Knockout of EPC1 effectively inhibited the growth of NPC cells, induced apoptosis, and inhibited invasion and metastasis. Inhibition of EPC1 could inhibit the EMT in NPC cells. All of the above findings support the viewpoint that EPC1 plays a pro-cancer role in NPC.
-
Multicenter Study
Prognosis and Long-Term Overall Survival in Hypertensive Patients Undergoing Chronic Hemodialysis: A Multicenter Parametric Mixture Split-Population Analysis.
Hemodialysis (HD) patients face long-term complications which require ongoing dialysis and follow-up. The management of hypertension among HD populations has often been neglected. This study aimed at identifying the determinants of death in hypertensive HD (HTN-HD) patients. ⋯ The split-population analyses were able to demonstrate that the predictors of long-term OS were different from those of short-term OS. Although the superiority of the parametric EGG model was proved in this study, further research with different databases is suggested. Moreover, these findings can be considered by health policy decision-makers to create a new guideline to enhance the long-term OS of HTN-HD patients.
-
The COVID-19 outbreak is currently a critical challenge, and proper perception of the mental health situation of individuals in the working environments has become a crucial issue. This study aimed to investigate the psychological and psychosocial impact during the COVID-19 pandemic among Iranian oil refineries personnel. ⋯ The COVID-19 pandemic can significantly affect the psychological and psychosocial parameters of employees in working environments. Therefore, implementing psychological interventions is absolutely necessary to promote personnel's mental health during the COVID-19 pandemic.
-
Coronary sinus dimension is an important factor for diagnosing some types of cyanosis as well as congenital heart diseases and insertion of some devices into the coronary sinus if required. This study was designed to access the diameter and Z-score of the coronary sinus among children under 18 years of age. ⋯ Coronary sinus diameter significantly correlates with the age, height, and body surface area of the cases. These features are useful in diagnosing some congenital heart diseases and insertion of suitable devices through it.