Arch Iran Med
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It is important to identify new biomarkers for early detection of complications and treatment success in patients with brucellosis. ⋯ These biomarkers are cost-effective, simple and broadly available parameters for predicting complications and specific organ involvement of brucellosis.
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Biography Historical Article
Louis-Pierre Delpy: A French Scholar and Former Director of the Razi Institute of Iran (1931-1951).
Delpy came to Iran as the third director of the Hesarak Vaccine and Serum Institute (Razi) in 1931 and revolutionized the institute by performing diagnostic and vaccine-producing techniques for 20 years. Dr. Delpy, as a veterinary microbiologist, was employed partly to control the outbreaks of rinderpest, but he did more important and lasting work in controlling other infectious and parasitic diseases, production of serums and vaccines, and developing tick taxonomy in Iran. Delpy was a very modest scientist who died in 1974 in France.
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There is no clear picture regarding the prevalence rates of autism and its comorbidities among Iranian children and adolescents. The present study aimed to estimate these rates as part of a large national population-based study on epidemiology of psychiatric disorders in Iranian children and adolescents. ⋯ The present study shows high prevalence rates for autism and its comorbid conditions among Iranian children and adolescents. It also reveals that there is a relationship between some maternal psychiatric disorders and the risk of autism.
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Meta Analysis
Prolonged versus Intermittent Infusion of Antibiotics in Acute and Severe Infections: A Meta-analysis.
Acute and severe infections are an absolute indication for the use of intravenous broad-spectrum antibiotics. However, previous studies have found inconsistent clinical advantages of prolonged (extended [≥3-hour infusion] or continuous [24-hour fixed rate infusion]) over intermittent (6, or 8, or 12 interval hours infusion) infusion. The clinical superiority between prolonged and intermittent infusion in treating acute and severe infections thus continues to be elusive. We conducted a meta-analysis to summarize all published randomized controlled trials (RCTs), prospective and retrospective observational studies to determine whether prolonged infusion, compared to intermittent infusion, is correlated with lower mortality and better clinical outcome. ⋯ Better outcomes in hospitalized patients, especially in those who were critical ill, were reported in prolonged infusion of intravenous antibiotics compared with traditional intermittent infusion.