Bratisl Med J
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The latest research outcomes indicate that metallothionein (MT) levels in peripheral blood and serum from cancer patients can provide many interesting information about type or clinical stage of the disease, or response to therapy. MT plays a key role in transport of essential heavy metals, detoxification of toxic metals and protection of cells against oxidation stress. ⋯ Automated electrochemical detection of MT allows its serial analysis in a very small volume with excellent sensitivity, reliability and reproducibility and therefore it can be considered as a new tool for cancer diagnosis (Fig. 4, Ref. 55). Full Text (Free, PDF) www.bmj.sk.
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Randomized Controlled Trial Comparative Study
Direct current therapy with/without lidocaine iontophoresis in myofascial pain syndrome.
This study aimed to assess the effectiveness of lidocaine iontophoresis for inactivation of trigger points (TrPs) in the treatment of myofascial pain syndrome (MPS). ⋯ Direct current therapy with/without lidocaine iontophoresis were determined to be effective treatment modalities in TrP management. These treatment modalities are non-invasive, cost effective and provide long term improvement. Thus, these modalities could be safely used in the management of MPS with minimal side effects, particularly if patients may not accept injection or other treatments (Tab. 3, Ref. 44). Full Text (Free, PDF) www.bmj.sk.
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The purpose of this study was to evaluate upper airway in obstructive sleep apnea-hypopnea syndrome patients and habitual snorers, and to determine the correlation with apnea-hypopnea index. ⋯ Obstructive sleep apnea-hypopnea patients results from changes in the upper airway. Anatomic and functional findings correlated with the apnea-hypopnea index. In the majority of patients with OSAHS, pharyngeal abnormalities and nasal obstruction were found to be statistically significant (Tab. 2, Fig. 1, Ref. 14).
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The purpose of this paper was to identify the impact of intoxicated road users upon the degree of responsibility for fatal road traffic accidents. ⋯ The degree of responsibility for fatal road traffic accidents was 1.5 times higher among intoxicated road users than among non-intoxicated road users. Alcohol is still the most abused psychoactive substance in Slovakia. The causes of its excessive consumption are the objectives of many larger studies. It is assumed that excessive alcohol consumption can be considerably attributed to its easy availability and lack of awareness and personal responsibility of road users (Tab. 4, Ref. 35).
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Monosodium glutamate (MSG) is a commonly used flavor enhancer in modern nutrition. It has been shown that administration of MSG induces toxic effects in various regions of brain, thymus, liver and kidney. Also, it is well-documented that Vitamin C (ascorbic acid) has a protective role in MSG-induced cytotoxicity in rat liver, kidney and various brain regions, but has not been studied in thymus. ⋯ These results suggest that the treatment with Vitamin C may prevent the MSG-induced cytotoxicity in rat thymocytes by up-regulating Bcl-2 protein expression resulting in a change in Bcl-2/Bax protein ratio (Tab. 1, Fig. 1, Ref. 32). Full Text (Free, PDF) www.bmj.sk.