Bratisl Med J
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To highlight the components of stripping operation of the great saphenous vein and to offer a proposal for guidelines. ⋯ While the patients who were operated on for the second time regained their health, others became the epitome of hopelessness and mistrust. They lost their confidence in medicine and surgery. If a stripping operation is planned, it should be performed in full accordance with the surgical procedure of stripping as mentioned in the classical textbooks. Guidelines should contain expressions reminding of ethical issues. This will prevent the dereliction of the duty and the loss of money, labor, time, health, patients' confidence in surgery (Tab. 1, Fig. 1, Ref. 18) Keywords: ethics, malpractice, quality of life, venous, saphenous, stripping.
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Review
Rationale Use of Neutrophil-to-lymphocyte ratio for early diagnosis and stratification of COVID-19.
Coronavirus disease is caused by a virus that is the cause of a potentially fatal disease worldwide. Coronavirus is a pathogen that primarily affects the human respiratory system. Coronavirus 2019 (COVID-19) has been named WHO since February 11, 2020. ⋯ In some cases, multiple inflammations have been observed. Treatment with interferon inhalation showed no clinical effect and the condition worsened instead (Tab. 5, Fig. 1, Ref. 18). Keywords: neutrophil-to-lymphocyte ratio, corona virus SARS-CoV-2, COVID-19.
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Recent breakthrough recognition of metastasis-free survival as a clinically relevant endpoint has opened a new era in the management of advanced prostate cancer. The need for new, intermediate endpoints is the logical consequence of scientific advances in prostate carcinoma. The treatment algorithms for non-metastatic castration-resistant prostate cancer (M0 CRPC) have recently been updated by adding novel anti-androgen apalutamide, and also enzalutamide for high-risk patients. ⋯ The metastasis-free survival can be considered a clinically significant and reliable efficacy endpoint in both localized prostate cancer patients and M0 CRPC patients being at high-risk of disease progression (Ref. 15).
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Inherited metabolic disorders of glycoconjugate metabolism include congenital disorders of glycosylation (CDG) - disorders in biosynthesis of glycoconjugates; and some of the lysosomal storage diseases (LSD) - disorders of their degradation. This review summarizes the brief characteristics of metabolic pathways of synthesis and catabolism of glycoconjugates as well as the latest update of relevant enzymatic defects discovered in population. Every year the number of known subtypes of these disorders dramatically increases as a result of high-throughput analytical infrastructure applied. ⋯ Thus, disorders of glycoconjugate metabolism should be considered and ruled out in any unexplained syndrome. The collaboration between scientists and physicians plays an important role in the progress of such personalized diagnostics, that is essential mainly for rare diseases (Tab. 2, Fig. 1, Ref. 49). Keywords: congenital disorders of glycosylation, lysosomal storage disorders.
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In this narrative review, our aim was to clarify the roles of diagnostic methods used in COVID-19 disease. ⋯ There is a need for an algorithm, which involves a combination of PCR and CT in diagnosis of COVID-19 (Ref. 85).