Bratisl Med J
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Type 2 Diabetes Mellitus (DM2) can lead to autonomic nervous system dysfunction and heart rate variability (HRV) is often used to assess this system both during rest and during physical exercise. ⋯ There was no difference between the groups in the modulation of rest or in the parasympathetic adjustments of the exercise (Tab. 4, Ref. 32).
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The objective of the research is to determine the levels of vitamin D and trace elements in the umbilical cord blood, as well as to evaluate the clinical and laboratory characteristics in premature newborns with congenital pneumonia. ⋯ Our results demonstrated a high prevalence of 25 (OH) vitamin D deficiency in premature newborns. A significant relationship has been shown between the respiratory status of vitamin D and presence of congenital pneumonia in premature newborns. The analysis also showed that the content of trace elements in premature newborns plays an immunomodulatory role and affects the susceptibility and outcome of the infectious process. Thrombocytopenia in premature newborns may be an early biomarker for monitoring congenital pneumonia (Tab. 2, Ref. 28). Text in PDF www.elis.sk Keywords: congenital pneumonia, premature newborn, vitamin D, trace elements, mass spectrometry.
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The pregnancy is accepted as an independent risk factor for restless legs syndrome/Willis-Ekbom disease (RLS/WED). The neutrophil-to-lymphocyte ratio (NLR) was recently reported in the pathophysiology of RLS/WED. In this report, we investigated the relationship between the presence of RLS/WED and the levels of NLR in pregnancy. ⋯ These results may suggest that an increased inflammation demonstrated by the increased NLR, may, in part, play a role in higher prevalence of RLS/WED in pregnancy, especially in late gestational weeks (Tab. 2, Fig. 1, Ref. 34). Text in PDF www.elis.sk Keywords: neutrophil-to-lymphocyte ratio, restless legs syndrome/Willis-Ekbom disease, pregnancy, inflammation.
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The study presents associations between prevalence of chronic diseases and selected socio-economic (SES) attributes in adult population of Slovakia and analyses the prevalence of chronic diseases in regions of Slovakia. ⋯ The study did not confirm a higher prevalence of chronic diseases in regions with weaker SES in Slovakia. Out of the 4 monitored SES attributes, 3 of them (age, education and lifestyle) had a significant impact on the prevalence of chronic diseases. Household income showed only a minimal association with the prevalence of chronic diseases, but this interdependence was not significant (Tab. 6, Ref. 41). Text in PDF www.elis.sk Keywords: socio-economic status, chronic diseases, age, household income, education.
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Observational Study
Predictive value of infliximab trough levels in maintenance therapy for 5-year sustained clinical remission in patients with inflammatory bowel disease.
Despite long-term use of infliximab (IFX) in IBD treatment, its optimized use is unclear due to its complicated pharmacokinetics/dynamics. Hence, the predictive value of IFX trough levels (TL) is important in treatment management. ⋯ TL > 3 µg/ml during maintenance therapy is a strong predictor of sustained clinical remission for 5 years in UC patients. The use of combination therapy with AZA, due to its significant association with high TL, may have a practical benefit in achieving better clinical outcomes in UC patients (Tab. 2, Fig. 10, Ref. 20).