Bratisl Med J
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Vasculitis in childhood is a result of a spectrum of causes ranging from idiopathic conditions with primary vessel inflammation to syndromes after exposure to recognized antigenic triggers, such as infectious agents and drugs causing hypersensitivity reactions. Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood. Although there is often a history of a recent or simultaneous upper respiratory tract infection, no consistent causative organism is found. We report an 11-year old boy with HSP and brucellosis and we speculated that brucellosis was the trigger agent for HSP (Ref. 13). ⋯ brucellosis, trigger agent, Henoch-Schönlein purpura, vasculitis, infectious agents, drug, hypersensitivity reactions, primary vessel inflammation.
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In this study, we investigated the protective effects of frequently used intravenous anesthetics (ketamine, propofol, thiopental, and fentanyl) in oxidative stress in a rat liver model of obstructive jaundice. ⋯ Ketamine and propofol were observed to cause the least amount of oxidative stress in this rat model of induced oxidative stress generated by ligation of the common bile duct. This experiment is the first study on this subject in the literature (Tab. 3, Ref. 65).
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Comparative Study
Percutaneous dilation tracheostomy versus surgical tracheostomy in critically ill patients.
This study was done to compare surgical tracheostomy and percutaneous dilation tracheostomy in respect to their early postoperative complications in critically ill patients. ⋯ Percutaneous dilation tracheostomy is an equally safe method compared with surgical tracheostomy. While posing the same perioperative risk, it requires neither the transport to the operating theater, nor the presence of the whole surgical team. In the early postoperative period, it significantly reduces the complications, mainly infections in a critically ill patient. The latter benefits make it a method of choice in elective tracheostomies at ICU (Tab. 2, Ref. 11).
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We presented a pandemic H1N1 2009 influenza virus infection in two pregnant women who were referred to the intensive care unit (ICU) with a rapidly progressive disease course. Both women had unremarkable past medical history. The first woman had the symptoms of fever, cough, dyspnea and tachypnea lasting for four days. ⋯ The second woman was intubated for two days in ICU. Both women showed a gradual improvement in their follow up and were discharged. Early admission, prompt diagnosis and early recourse to antiviral treatment gives better results in H1N1 infected pregnant women (Fig. 2, Ref. 10).
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The aim of our study was to evaluate impact of CYP2D6 and MDR1 polymorphisms on the analgesic efficacy of tramadol in patients after a knee arthroscopy. ⋯ CYP2D6 plays a significant role in tramadol analgesic efficacy. The non-opioid analgesia in PMs was associated with better subjective pain relief in patients after a knee arthroscopy (Tab. 3, Ref. 18).