Cochrane Db Syst Rev
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Cochrane Db Syst Rev · Jun 2024
Review Meta AnalysisPeripherally inserted central catheter design and material for reducing catheter failure and complications.
Peripherally inserted central catheters (PICCs) facilitate diagnostic and therapeutic interventions in health care. PICCs can fail due to infective and non-infective complications, which PICC materials and design may contribute to, leading to negative sequelae for patients and healthcare systems. ⋯ There is limited high-quality RCT evidence available to inform clinician decision-making for PICC materials and design. Limitations of the current evidence include small sample sizes, infrequent events, and risk of bias. There may be little to no difference in the risk of VTE, PICC-associated BSI, occlusion, or mortality across PICC materials and designs. Further rigorous RCTs are needed to reduce uncertainty.
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Cochrane Db Syst Rev · Jun 2024
Cytoreductive surgery plus chemotherapy versus chemotherapy alone for recurrent epithelial ovarian cancer.
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of secondary CRS and chemotherapy in comparison to chemotherapy alone for women with platinum-sensitive recurrent epithelial ovarian cancer.
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Cochrane Db Syst Rev · Jun 2024
Review Meta AnalysisTopical fluoride as a cause of dental fluorosis in children.
This is an update of a review first published in 2010. Use of topical fluoride has become more common over time. Excessive fluoride consumption from topical fluorides in young children could potentially lead to dental fluorosis in permanent teeth. ⋯ Most evidence identified mild fluorosis as a potential adverse outcome of using topical fluoride at an early age. There is low- to very low-certainty and inconclusive evidence on the risk of having fluorosis in permanent teeth for: when a child starts receiving topical fluoride varnish application; toothbrushing with fluoride toothpaste; the amount of toothpaste used by the child; and the frequency of toothbrushing. Moderate-certainty evidence from RCTs showed that children who brushed with 1000 ppm or more fluoride toothpaste from one to two years of age until five to six years of age probably had an increased chance of developing dental fluorosis in permanent teeth. It is unethical to propose new RCTs to assess the development of dental fluorosis. However, future RCTs focusing on dental caries prevention could record children's exposure to topical fluoride sources in early life and evaluate the dental fluorosis in their permanent teeth as a long-term outcome. In the absence of these studies and methods, further research in this area will come from observational studies. Attention needs to be given to the choice of study design, bearing in mind that prospective controlled studies will be less susceptible to bias than retrospective and uncontrolled studies.
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Cochrane Db Syst Rev · Jun 2024
Using evidence from civil society in national and subnational health policy processes: a qualitative evidence synthesis.
This is a protocol for a Cochrane Review (qualitative). The objectives are as follows: To explore the use of evidence from civil society in national and subnational health policy processes. The specific research questions will include the following. How is evidence from civil society incorporated into health policy processes and what types of evidence are (or are not) incorporated? How do civil society actors perceive and experience the use of their evidence in health policy processes? How do decision-makers, healthcare providers and other stakeholders in health policy processes experience and use civil society evidence, and what factors affect this process? What are civil society actors', healthcare providers', decision-makers' and other stakeholders' views and experiences of how evidence from civil society actors influences inclusiveness, responsiveness and accountability within health policy processes?
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Cochrane Db Syst Rev · Jun 2024
ReviewUltrasound and blind endometrial sampling for detection of endometrial cancer in women with postmenopausal bleeding.
This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To assess the diagnostic accuracy of endometrial sampling with histology in the diagnosis of endometrial cancer in women with postmenopausal bleeding and thickened endometrium on ultrasound. Diagnosis will be verified by the reference standards, hysteroscopy with histology, obtained by targeted (such as grasp biopsy of the endometrium or resection of focal pathology) or global sampling (with dilation and curettage), and histology of hysterectomy specimens. Secondary objectives To determine the diagnostic accuracy of different sampling devices and methods in the detection of endometrial cancer To assess the diagnostic accuracy of endometrial sampling devices and methods to detect endometrial hyperplasia To determine accuracy in diagnosing endometrial cancer and endometrial hyperplasia at different endometrial thicknesses of 3 mm, 4 mm and 5 mm To investigate sources of heterogeneity.