Int J Med Sci
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Background: Atherosclerosis, a chronic inflammatory disease, poses a significant risk for cardiovascular disorders. Meanwhile, emerging evidence suggests that long noncoding RNAs (lncRNAs) play pivotal roles in diverse cardiovascular conditions. Nonetheless, the functional implications of lncRNAs in atherosclerosis remain largely unexplored. ⋯ Specifically, we demonstrate that HOTAIR plays a role in alleviating foam cell formation and suppressing the inflammatory response by inhibiting miR-19a-3p in the context of atherosclerosis. Our results suggest the involvement of the TNF-α/miR-19a/HBP1/MIF pathway in mediating these effects. These findings contribute to a better understanding of atherosclerosis's molecular mechanisms and highlight the potential therapeutic implications of targeting HOTAIR and its associated pathways.
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Purpose: CT angiography-source image (CTA-SI) can be used as an effective alternative to diffusion-weighted imaging (DWI) for identifying acute ischemic stroke (AIS). This study investigates the reliability of combining CTA-SI with non-contrast CT (NCCT) for AIS diagnosis, with a focus on how different brain areas affect diagnostic accuracy. Methods: Patients with various subtypes of AIS who underwent NCCT, CTA, and DWI from January to December 2022 were included. ⋯ The NCCT+CTA-SI model demonstrated higher lesion detection rate than the NCCT (59.20% vs 48.7%, p<0.05) and CTA-SI model (59.2% vs 45.4%, p<0.05), particularly when detecting large vessel trunk infarction (82.90% vs 58.60%, p<0.05) and deep perforator vessel infarctions (64.80% vs 44.40%, p<0.05). Conclusions: The NCCT+CTA-SI model may be a valuable tool for evaluating AIS when DWI is not feasible. Smaller hospitals might consider adopting this combination for improved stroke diagnosis, highlighting the need for careful evaluation of deep perforator vessel infarction when large vessel trunk infarction is not evident.
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The most general cancer in men is prostate cancer (PCa), with its risk increasing due to age and obesity. Visfatin, a member of adipokines, is related to cancer progression and metastasis, but its relationship in PCa remains undetermined. In addition, no knowledge is available regarding relations between visfatin polymorphisms and clinicopathological characteristics in PCa. ⋯ Visfatin rs61330082 and rs11977021 were related with a high risk of perineural invasion, lymphovascular invasion, and biochemical recurrence in prostate-specific antigen (PSA) > 10 PCa patients. The Cancer Genome Atlas database noted that visfatin mRNA level did not prominently differ with pathological T/N stage and overall survival. This finding is the first to document a connection between visfatin polymorphisms and clinicopathological characteristics of PCa in Taiwanese males.
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Background: Acute kidney injury (AKI) is a frequent complication in patients undergo-ing cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) due to a combination of several factors: increased intra-abdominal pressure, heat stress and drug tox-icity. Methods: Patients admitted to Intensive Care Unit after CRS and HIPEC during 129 months. Data recorded were: demographic characteristics; severity of illness, haematology and basic chemistry panels (renal function and electrolytes), type of cancer and extension, HIPEC drug and temperature, fluid balance, ICU and hospital stay and mortality. ⋯ The presence of hydroelectrolytic alterations and polyuria was very frequent. The type of cancer, no mitomycin-based regimens and positive fluid balance during surgery were factors that suggest increased risk of AKI. However, although patients with AKI were clinically worse it was not associated with higher mortality.
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Purpose: To investigate the influence of different keratometry (K) measurements on the postoperative outcomes of cataract surgery with extended depth-of-focus (EDOF) intraocular lens (IOL) implantation. Methods: A retrospective cohort study was conducted, and patients who received cataract surgery and one type of EDOF IOL implantation were included. The patients were then categorized according to K measurements, and 70 and 30 eyes were included in the biometric-K and topographic-K groups, respectively. ⋯ According to the multivariate analysis, the topographic-K group presented a significantly better UDVA (P = 0.044) and significantly lower cylinder power (P = 0.031) than the biometric-K group. Angle kappa was significantly correlated with high postoperative astigmatism in the topographic-K group (P = 0.033), whereas angle kappa, steep K, and corneal cylinder powers were significantly correlated with high postoperative astigmatism in the biometric-K group (all P < 0.05). Conclusion: Topography-based K measurements yielded better refractive outcomes than biometric-based K measurements did.