Isr Med Assoc J
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Multicenter Study Observational Study
European Registry on Helicobacter pylori management (Hp-EuReg): First-line Therapy in Israel.
The antibiotic resistance profile of Helicobacter pylori (H. pylori) is constantly changing. Up-to-date and reliable data for the effectiveness of first-line H. pylori treatment protocols are necessary to provide evidence-based best-practice guidelines. ⋯ The effectiveness of clarithromycin-based triple therapy is suboptimal. First-line treatment of H. pylori infection should consist of four drugs, including high dose PPI, according to international guidelines.