J Res Med Sci
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This report describes a 66-year-old male who had a long history of hepatitis B virus (HBV) infection. He was found hepatocellular carcinoma (HCC) 5 months after lamivudine resistance mutation and then received a successful hepatectomy. Three years later, hepatitis B envelope antigen seroconversion was achieved and nucleoside analogs were discontinued. ⋯ Anti-HBV treatment improved the patient clinical condition. Three months after the remission of ACLF, the patient was diagnosed as HCC recurrence and received another hepatectomy. This case illustrates indefinite duration antiviral therapy and tight viral control should be performed in patients with HBV-related HCC.
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Prostate cancer is one of the most common cancer types both in western and eastern countries, involving mostly elder men. The mechanisms underlying the prostate cancer development remain unclear. Prostate-specific antigen (PSA) is the only well accepted marker for prostate cancer diagnosis and prognosis. The diagnosis and treatment of prostate cancer are facing big challenges. Here, we evaluated the expression of Dipeptidyl peptidase IV (CD26/DPPIV) and C-X-C chemokine receptor type 4 (CXCR4), two known cancer-related molecules but without clear data on prostate cancer population, and their correlation with clinical parameters in prostate cancer tissue array. To explore the correlation of CD26 and CXCR4 expression in prostate carcinoma and their relationship with clinical parameters. ⋯ Our data indicate that CD26 may be a good indicator for cancer behaviors of prostate cancer in clinic.
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Congenital hypothyroidism (CH) considered a common endocrine disorder in Iran. We report the epidemiologic findings of CH screening program in Isfahan, seven years after its development, regarding the prevalence of transient CH (TCH) and its screening properties comparing with permanent CH (PCH). ⋯ The higher rate of CH in Isfahan is mainly due to the transient form of the disease. Further studies for evaluating the role of other environmental, autoimmune and/or genetic factors in the pathophysiology of the disease is warranted.
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Hepatitis C virus (HCV) is the main causative agent of post-transfusion hepatitis. The virus is distributed worldwide with varying prevalence in different countries, which could easily lead to chronic infections, cirrhosis, and even hepatocellular carcinoma. The aim of this study was to investigate prevalence of HCV infection and its trend in Iranian blood donors. ⋯ This study provides a comprehensive and reliable data on the prevalence and trend of HCV infection among blood donors and may be helpful in providing insight into disease burden and opportunities for prevention. In comparison with countries in this geographic region, Iran has the lowest rate of HCV infection.
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There are different options to manage benign headache in the emergency department. The costs, side effects, and efficacies of the drugs used are significantly different. The aim of this study was to compare intravenous (IV) metoclopramide with subcutaneous (SC) sumatriptan in treatment of migraine headache. ⋯ For treatment of migraine headache, IV metoclopramide may be superior to SC sumatriptan in the emergency department.