Med Klin
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Randomized Controlled Trial Clinical Trial
[Effect of selenium administration on various laboratory parameters of patients at risk for sepsis syndrome].
Low selenium plasma levels were often measured in ICU patients with polytrauma, major surgery or various severe diseases. Activation of selenium-dependent functions of the antioxidant metabolism and the immune system is suggested to be causally. ⋯ 1. Rapid normalization of selenium plasma levels can be achieved with the applied selenium dosage. 2. Parameters of radical metabolism are significantly reduced following selenium administration. 3. T3 synthesis correlates closely with the selenium levels. 4. Excessive stimulation of the immune system does not appear in the applied dosage.
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Randomized Controlled Trial Clinical Trial
[Selenium administration in patients with sepsis syndrome. A prospective randomized study].
In this study the effect of antioxidative therapy with sodium selenite was investigated in patients with systemic inflammatory response syndrome (S. I. R. S.) and multiple organ failure. 40 patients were included in this prospective randomized study. The patients were observed over a period of 28 days. The letality rate within 28 days was excepted as main criteria. The Apache-II and the MOF-Score of Goris were used as clinical parameters. 20 patients were treated with sodium selenite over a period of 28 days. ⋯ This antioxidative therapy reduced the letality rate from 40 to 15%.
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Randomized Controlled Trial Clinical Trial
[Selenium administration in sepsis patients].
It has been hypothesized that low serum selenium concentrations, associated with low glutathione peroxidase activities in critical ill patients may contribute to decreased cleavage from free radicals and deteriorate the clinical outcome. ⋯ Selenium substitution significantly improves clinical outcome and reduces the incidence of acute renal failure.