Pak J Med Sci
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Encephalocele is a congenital neural tube defect (NTD). The pathophysiology of the NTDs is exceedingly complex. Numerous explanations have been proposed to explain it. ⋯ Double encephalocele is a rare entity. The multisite closure theory appears to be the most plausible explanation for the development of multiple NTDs. The management of double encephalocele requires a case based approach.
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Healthcare workers are at a higher risk of burnout. The aim of the study was to explore the professional quality of life (QOL) i.e. {Compassion Satisfaction (CS), Burnout (BO) and Secondary Traumatic Stress (STS)} and association of different trainee factors on QOL amongst Pediatric specialty trainees at a private tertiary care hospital in Karachi, Pakistan. ⋯ This study delves into the professional quality of life and offers valuable understanding into the specific events encountered by trainees.
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To examine the expression of circular ribonucleic acid (circRNA) in the peripheral blood of pregnant women with preeclampsia (PE) prior to the onset of the disease. ⋯ CircRNAs are involved in a variety of biological processes and regulatory network related to the pathogenesis of PE.
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We aimed to determine frequency, clinical presentation, etiology and management in patients presenting with primary amenorrhea in tertiary care setting. ⋯ Primary amenorrhea is a significant problem in adolescent girls. We found Mayer Rokitansky- Kuster- Hauser syndrome (MRKH) syndrome as the commonest cause in our series. There is need to promptly identify the patients who need medical, surgical or psychological management. It is also required to make local strategies and guidelines for evaluation, management and long term follow up.
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To evaluate the Outcomes of Fenestration of Lamina Terminalis for Hydrocephalus following Clipping of Ruptured Aneurysms of Anterior Circulation. ⋯ Reducing the likelihood of shunt-dependent hydrocephalus after ruptured aneurysm clipping can be achieved using lamina terminalis fenestration, regardless of fisher grade. It assists in preventing excessive brain retraction, decreasing intracranial pressure, raising brain perfusion, cisternal blood cleansing, and lowering the need for a ventriculoperitoneal shunt in cases of persistent hydrocephalus. Consequently, to reduce the incidence of shunt-dependent hydrocephalus, we recommend routine lamina terminalis fenestration following anterior circulation aneurysm clipping.