Pak J Med Sci
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Blood Stream Infections (BSI) are considered a significant cause of morbidity and mortality in patients with Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). We aimed to identify risk factors for BSI upon admission, highlight clinical and microbiological findings and ascertain the frequency of mortality in patients with BSI in SJS/TEN. ⋯ Vigilant monitoring and early detection of BSI in SJS/TEN patients, especially those presenting with high SCORTEN scores can enhance clinical outcomes.
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Scattered white spots (SWS) seen in the duodenum during esophagogastroduodenoscopy are rare lesions. The histopathologic examination of SWS lesions reveals normal duodenal mucosa (ND), chronic nonspecific duodenitis, and intestinal lymphangiectasia (IL). The intestinal epithelium, through its barrier function, is responsible for tightly controlling antigen traffic from the intestinal lumen to the submucosa. Zonulin plays a crucial role in intestinal barrier function. In this study, we aimed to determine whether there is a relationship between zonulin, the most important marker of leaky gut syndrome, and SWS lesions associated with lymphatic stasis and inflammation in the duodenum. ⋯ Patients with identified SWS more frequently exhibit IL and gastric metaplasia. There is no relationship between SWS and serum zonulin levels.
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To determine the incidence of postoperative cerebrospinal fluid (CSF) leaks after endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenomas without sellar floor reconstruction (SFR). ⋯ Pituitary adenomas can be successfully treated with EETS without SFR in patients who do not experience intraoperative CSF leak.
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Controlled ovarian stimulation (COS) and embryo culture may affect the development and maturation of oocytes obtained by assisted reproduction technologies (ART). This study used the concept of available oocytes rate (AOR) to evaluate the effect of COS and to identify factors that influence oocyte development and clinical pregnancy (CP). ⋯ The AOR is an important indicator of oocyte function and is correlated with clinical pregnancy outcomes of fresh cycles. The AOR could objectively predict HMG as a clinically related factor that affected the number and maturation of oocytes for insemination.
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To explore the hepatoprotective effect of diammonium glycyrrhizinate (DG) in the treatment of pulmonary tuberculosis. ⋯ In the treatment of pulmonary tuberculosis, combining DG with conventional anti-tuberculosis regimen can improve overall intervention effect, reduce incidence of liver injury, and alleviate its degree.