Presse Med
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Randomized Controlled Trial Clinical Trial
[Efficacy and tolerance of an effervescent aspirin-metoclopramide combination in the treatment of a migraine attack. Randomized double-blind study using a placebo].
A double blind, randomized, multicenter, parallel group study was carried out to compare the efficacy and tolerance of aspirin 900 mg-metoclopramide 10 mg effervescent association (AAM) with those of placebo in the treatment of acute migraine attack. All patients were selected according to the International Headache Society criteria. ⋯ It is concluded that the aspirin-metoclopramide association may be used as a first intention treatment of acute migraine attack in out-patients.
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Randomized Controlled Trial Clinical Trial
[Effects of anesthesia on higher brain functions in the elderly].
Sixty-four patients aged over 60 about to undergo elective surgery of the lower limbs were allocated at random to two groups, one with general anaesthesia, the other with local/regional anaesthesia, in order to compare the effects of these two types of anaesthesia on superior brain functions. The two groups were similar in age, disease, treatment and risk from anaesthesia. ⋯ The score decreased to pathological values (less than or equal to 20) in 4 patients from the local/regional anaesthesia group, and this fall was associated with trans- and postoperative incidents (haemorrhage, cardiorespiratory arrest, confusion after receiving pethidine, cardiac decompensation). This study shows that alterations of the superior brain functions are probably related to trans and postoperative incidents rather than to the type of anaesthesia administered.
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Randomized Controlled Trial Clinical Trial
[Absence of effect of enalapril on the glycemic control and peripheral sensitivity to insulin in 10 diabetic patients treated with subcutaneous continuous infusion of insulin].
In diabetic patients, it has been suggested that angiotensin converting enzyme inhibitors may be associated with unexplained hypoglycaemic episodes. Such a side effect may limit the use of these drugs in diabetic hypertensive patients. Ten insulin-dependent diabetic patients mean age 38.4 +/- 13.1 years, mean diabetes duration 10.3 +/- 6.6 years (m +/- SD) were selected on the basis of good glycaemic control: HbA1: 7.6 +/- 0.9 per cent (upper limit of normal value less than 7.5 per cent) on continuous subcutaneous insulin infusion. ⋯ The incidence of hypoglycaemic episodes was similar. Neither peripheral insulin sensitivity was modified by enalapril. In the conditions of this study, enalapril did not interfere with glycaemic control in insulin-dependent diabetics in good metabolic control.
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Randomized Controlled Trial Comparative Study Clinical Trial
[Preoperative skin preparation. A prospective study comparing a depilatory agent in shaving].
Two types of pre-operative skin preparation were compared in a prospective randomized study conducted on 100 patients undergoing elective surgery: 51 patients were shaven (group I) and 49 were prepared with a depilatory agent. In all cases skin preparation was performed on the eve of the operation. Bacterial density, measured immediately before surgery by application of a contact agar preparation was 493 +/- 928 CFU in group I and 386 +/- 670 CFU in group II (NS). ⋯ In addition, the depilatory agent proved bactericidal against 3 pathogenic strains (S. aureus, Pseudomonas aeruginosa and E. coli). Depilation with a chemical agent seems to be a satisfactory method of pre-operative skin preparation. It is more rapid than shaving, it can be applied to areas not easily accessible to razors, and it can often be carried out by the patient himself.
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Randomized Controlled Trial Clinical Trial
[Laryngeal edema after extubation. Do corticosteroids play a role in its prevention?].
The role of corticosteroids in the prevention of post-extubation laryngeal oedema was evaluated in a randomized study of 276 patients under mechanical ventilation. Fifty per cent of the patients received methylprednisolone 40 mg intramuscularly and intravenously. ⋯ Thus, the incidence of laryngeal oedema was not modified by corticosteroids. Regular prescription of corticosteroids does not seem to be useful before extubation of patients intubated with large volume, low-pressure balloon tubes.