Saudi Med J
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Multicenter Study
Epidemiology of Clostridioides difficile infection at a tertiary care facility in Saudi Arabia: Results of prospective surveillance.
To determine the incidence of Clostridioides difficile infection (CDI) and the frequency of known risk factors. ⋯ In our hospital, HO-CDI incidence rate is lower than that in high-income countries. National multicenter surveillance is needed to evaluate the actual burden of CDI in Saudi Arabia.
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To study the clinical evaluation of recurrent respiratory papillomatosis (RRP) patients and the factors associated with the improvement in the Derkay's score as a measure of disease severity. ⋯ cidofovir treatment and higher Derkay's scores affected the disease improvement.
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To determine the occurrence of Group B Streptococcus (GBS) infection in neonates and its associated risk factors in Al-Madinah Al-Munawarah, Saudi Arabia. ⋯ Neonatal GBS infection is prevalent in Al-Madinah Al-Munawarah. Several risk factors may contribute to the occurrence of GBS infection including preterm labor, higher body temperature during delivery, prolonged premature rupture of membranes for more than 18 hours, and GBS bacteriuria. We recommend that larger multi-centric studies are needed in Al-Madinah Al-Munawarah, to study the magnitude of neonatal GBS infection and risk factors to develop a screening protocol in maternity and children's hospital.
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Observational Study
Determining optimal cuff volume for cuffed endotracheal tubes commonly used in pediatric patients: A prospective observational study.
To determine an optimal cuff inflation volume to achieve safe cuff pressure (20-25 cmH2O) in cuffed endotracheal tubes (ETTs) with an inner diameter of 4.5, 5.0, and 5.5 mm, which are commonly used in pediatric anaesthesia clinical practice and to create a formula to determine the optimal cuff volume. ⋯ In this study, we suggested the optimal cuff volume to inflate the cuffs of ETTs 4.5, 5.0, and 5.5, which are frequently used in pediatric anaesthesia practice, in the appropriate cuff pressure range.ClinicalTrials.gov ref. no.: NCT04948359.
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To investigate the role of cell cycle protein-dependent kinase regulatory subunit 1B (CKS1B) in driving the aggressive and rapid proliferation observed in pancreatic cancer. ⋯ The CKS1B may serve as a novel potential prognostic factor in pancreatic cancer and is involved in the abnormal proliferation biology phenotype by mediating cell cycle signaling pathways.