Neurology
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Randomized Controlled Trial Comparative Study Clinical Trial
A comparison of neuropsychological effects of thalamotomy and thalamic stimulation.
The neuropsychological effects of thalamotomy and thalamic stimulation in patients with severe drug-resistant tremor due to PD, essential tremor (ET), or MS were compared in a randomized trial. ⋯ Both thalamotomy and thalamic stimulation are associated with a minimal overall risk of cognitive deterioration. Verbal fluency decreased after both left-sided thalamotomy and thalamic stimulation.
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Randomized Controlled Trial Comparative Study Clinical Trial
Economic evaluation of spinal cord stimulation for chronic reflex sympathetic dystrophy.
To evaluate the economic aspects of treatment of chronic reflex sympathetic dystrophy (RSD) with spinal cord stimulation (SCS), using outcomes and costs of care before and after the start of treatment. ⋯ The authors found SCS to be both more effective and less expensive as compared with the standard treatment protocol for chronic RSD.
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Randomized Controlled Trial Comparative Study Clinical Trial
Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial.
Tricyclic antidepressants (TCA) provide less than satisfactory pain relief for postherpetic neuralgia (PHN), and the role of opioids is controversial. ⋯ Opioids effectively treat PHN without impairing cognition. Opioids and TCA act via independent mechanisms and with varied individual effect.