Neurology
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures.
Pregabalin is an alpha(2)-delta ligand that has anxiolytic, analgesic, and anticonvulsant properties. ⋯ Adjunctive therapy with pregabalin 150, 300, and 600 mg/d, given in twice-daily doses without titration, is significantly effective and well tolerated in the treatment of patients with partial seizures as demonstrated in patients with refractory partial seizures.
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Multicenter Study
Spinal manipulative therapy is an independent risk factor for vertebral artery dissection.
To determine whether spinal manipulative therapy (SMT) is an independent risk factor for cervical artery dissection. ⋯ This case-controlled study of the influence of SMT and cervical arterial dissection shows that SMT is independently associated with vertebral arterial dissection, even after controlling for neck pain. Patients undergoing SMT should be consented for risk of stroke or vascular injury from the procedure. A significant increase in neck pain following spinal manipulative therapy warrants immediate medical evaluation.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trial.
To evaluate the efficacy and tolerability of lamotrigine (LTG) for the treatment of pain in HIV-associated sensory neuropathies. ⋯ Lamotrigine was well-tolerated and effective for HIV-associated neuropathic pain in patients receiving neurotoxic antiretroviral therapy. Additional research is warranted to understand the differing response among patients receiving neurotoxic antiretroviral therapy compared with those not receiving neurotoxic antiretroviral therapy.