Neurology
-
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Donepezil in vascular dementia: a randomized, placebo-controlled study.
-
Randomized Controlled Trial Multicenter Study Clinical Trial
A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis.
To determine if long-term topiramate therapy is safe and slows disease progression in patients with ALS. ⋯ At the dose studied, topiramate did not have a beneficial effect for patients with ALS. High-dose topiramate treatment was associated with a faster rate of decline in muscle strength as measured by MVIC and with an increased risk for several adverse events in patients with ALS. Given the lack of efficacy and large number of adverse effects, further studies of topiramate at a dose of 800 mg or maximum tolerated dose up to 800 mg/day are not warranted.