Neurology
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Randomized Controlled Trial Multicenter Study Clinical Trial
Efficacy of pergolide in treatment of restless legs syndrome: the PEARLS Study.
To evaluate the short- and long-term safety and efficacy of pergolide therapy for restless legs syndrome (RLS) in a double-blind, placebo-controlled, randomized trial (Pergolide European Australian RLS [PEARLS] study). ⋯ Pergolide substantially improves periodic limb movement measures and subjective sleep disturbance associated with restless legs syndrome. Low-dose pergolide was well tolerated and maintained its efficacy in the long term.