Neurology
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Randomized Controlled Trial Multicenter Study
Pentoxifylline in ALS: a double-blind, randomized, multicenter, placebo-controlled trial.
To assess the efficacy and safety of pentoxifylline, a US Food and Drug Administration-approved drug, in patients with ALS treated with riluzole. ⋯ Pentoxifylline is not beneficial in ALS and should be avoided in patients treated with riluzole. The discrepancy between survival and measures of functional changes urges caution in equating these end points in phase III trials, and suggests that both survival and function should be used in phase III trials.