Neurology
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Randomized Controlled Trial Multicenter Study
Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.
Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. ⋯ Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.
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To describe the emerging profile of headache frequency following a 2-month drug-free period in patients with medication overuse. ⋯ These data demonstrate the benefit of withdrawal in already established medication overuse and support the existence of medication-overuse headache as a clinical entity.
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Multicenter Study Clinical Trial
Neuropathology of older persons without cognitive impairment from two community-based studies.
To examine the relation of National Institute on Aging-Reagan (NIA-Reagan) neuropathologic criteria of Alzheimer disease (AD) to level of cognitive function in persons without dementia or mild cognitive impairment (MCI). ⋯ Alzheimer disease pathology can be found in the brains of older persons without dementia or mild cognitive impairment and is related to subtle changes in episodic memory.