Neurology
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Randomized Controlled Trial Comparative Study
Sodium valproate vs phenytoin in status epilepticus: a pilot study.
Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. ⋯ The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.
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Randomized Controlled Trial
A double-blind, controlled study of botulinum toxin A in chronic myofascial pain.
Recent studies have reported a potential analgesic effect of botulinum toxin A (BTXA) in musculoskeletal pain. The present double-blind, randomized, placebo-controlled, parallel clinical trial studied the effect of BTXA on pain from muscle trigger points and on EMG activity at rest and during voluntary contraction. ⋯ The results do not support a specific antinociceptive and analgesic effect of botulinum toxin A.