Neurology
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Meta Analysis
Meta-analysis of APOE genotype and subarachnoid hemorrhage: clinical outcome and delayed ischemia.
Emerging evidence suggests that the APOE4 allele may increase the risk of a negative outcome in patients with aneurysmal subarachnoid hemorrhage (SAH), but the results are conflicting. A genetic variable predicting the individual clinical course is currently lacking. ⋯ In patients with subarachnoid hemorrhage, the expression of the E4 allele is associated with a higher risk of a negative outcome and delayed ischemia.