Neurology
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Randomized Controlled Trial
A cluster-randomized trial to improve stroke care in hospitals.
We evaluated the effect of performance feedback on acute ischemic stroke care quality in Minnesota hospitals. ⋯ This study provides Class II evidence that informing hospital leaders of compliance with ischemic stroke quality indicators followed by a structured quality improvement intervention did not significantly improve compliance more than informing hospital leaders of compliance with stroke quality indicators without a quality improvement intervention.
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Randomized Controlled Trial
Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1.
To determine if mexiletine is safe and effective in reducing myotonia in myotonic dystrophy type 1 (DM1). ⋯ This study provides Class I evidence that mexiletine at dosages of 150 and 200 mg 3 times daily over 7 weeks is well-tolerated and effective in reducing handgrip relaxation time in DM1.