Neurology
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Multicenter Study Comparative Study
Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications.
To evaluate frequency, severity, and correlation of nonmotor symptoms (NMS) with motor complications in fluctuating Parkinson disease (PD). ⋯ Patterns of NMS fluctuations are heterogeneous and complex, but psychic NMS fluctuate more frequently and severely. Demographic parameters and motor function do not correlate with NMS or nonmotor fluctuation severities in fluctuating PD.
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Randomized Controlled Trial Multicenter Study
Migraine prevention with a supraorbital transcutaneous stimulator: a randomized controlled trial.
To assess efficacy and safety of trigeminal neurostimulation with a supraorbital transcutaneous stimulator (Cefaly, STX-Med., Herstal, Belgium) in migraine prevention. ⋯ This study provides Class III evidence that treatment with a supraorbital transcutaneous stimulator is effective and safe as a preventive therapy for migraine.
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Randomized Controlled Trial Multicenter Study
A randomized trial of pregabalin in patients with neuropathic pain due to spinal cord injury.
To assess the efficacy and tolerability of pregabalin for the treatment of central neuropathic pain after spinal cord injury (SCI). ⋯ This study provides class I evidence that pregabalin, 150 to 600 mg/d, is effective in reducing duration-adjusted average change in pain compared with baseline in patients with SCI over a 16-week period (p = 0.003, 95% confidence interval = -0.98, -0.20).