Neurology
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Randomized Controlled Trial
Hyperdopaminergic crises in familial dysautonomia: a randomized trial of carbidopa.
The purpose of this study was to determine whether carbidopa (Lodosyn), an inhibitor of dopa-decarboxylase that blocks the synthesis of dopamine outside the brain, is an effective antiemetic in patients with familial dysautonomia (FD) and hyperdopaminergic nausea/retching/vomiting attacks. ⋯ This study provides Class II evidence that carbidopa is effective in reducing nausea/retching/vomiting in patients with FD.