Neurology
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Randomized Controlled Trial Comparative Study
Randomized trial of IV valproate vs metoclopramide vs ketorolac for acute migraine.
We compared the efficacy of IV valproate with metoclopramide and with ketorolac in patients presenting to an emergency department (ED) with acute migraine. ⋯ This study provides Class I evidence that in ED patients with acute migraine, IV valproate is inferior to metoclopramide or ketorolac in improving headache outcomes.
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Randomized Controlled Trial Comparative Study
Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON) trial: main results.
To determine whether extracranial-intracranial (EC-IC) bypass can improve cognition over 2 years compared to best medical therapy alone in patients with symptomatic internal carotid artery (ICA) occlusion and increased oxygen extraction fraction (OEF) on PET. ⋯ This study provides Class II evidence that for patients with symptomatic ICA occlusion and increased OEF on PET, EC-IC bypass compared to no bypass does not improve cognitive function after 2 years.