Neurology
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Review Meta Analysis
Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis.
To identify factors influencing age at symptom onset and disease course in autosomal dominant Alzheimer disease (ADAD), and develop evidence-based criteria for predicting symptom onset in ADAD. ⋯ Significant proportions of the observed variance in age at symptom onset in ADAD can be explained by family history and mutation type, providing empirical support for use of these data to estimate onset in clinical research.