Neurology
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Multicenter Study Observational Study
Autoimmune post-herpes simplex encephalitis of adults and teenagers.
To report 14 patients with immune-mediated relapsing symptoms post-herpes simplex encephalitis (HSE) and to compare the clinical and immunologic features of the teenage and adult group with those of young children. ⋯ In teenagers and adults, the immune-mediated relapsing syndrome post-HSE is different from that known in young children as choreoathetosis post-HSE and is underrecognized. Prompt diagnosis is important because immunotherapy can be highly effective.
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Multicenter Study
New-onset refractory status epilepticus: Etiology, clinical features, and outcome.
The aims of this study were to determine the etiology, clinical features, and predictors of outcome of new-onset refractory status epilepticus. ⋯ Autoimmune encephalitis is the most commonly identified cause of new-onset refractory status epilepticus, but half remain cryptogenic. Outcome at discharge is poor but improves during follow-up. Epilepsy develops in most cases. The role of anesthetics and immune therapies warrants further investigation.