Neurology
-
Randomized Controlled Trial
Glycated albumin predicts the effect of dual and single antiplatelet therapy on recurrent stroke.
To determine the relationship of glycated albumin (GA) and the recurrence of stroke in patients on either dual or single antiplatelet therapy. ⋯ GA could be a potential biomarker to predict the effects of dual and single antiplatelet therapy in patients with minor stroke or TIA.
-
Randomized Controlled Trial Multicenter Study
Autologous hematopoietic stem cell transplantation in multiple sclerosis: a phase II trial.
To assess in multiple sclerosis (MS) the effect of intense immunosuppression followed by autologous hematopoietic stem cells transplantation (AHSCT) vs mitoxantrone (MTX) on disease activity measured by MRI. ⋯ Intense immunosuppression followed by AHSCT is significantly superior to MTX in reducing MRI activity in severe cases of MS. These results strongly support further phase III studies with primary clinical endpoints. The study was registered as EUDRACT No. 2007-000064-24.
-
Randomized Controlled Trial Multicenter Study
Randomized trial of vaccination in fingolimod-treated patients with multiple sclerosis.
To evaluate immune responses in fingolimod-treated patients with multiple sclerosis (MS) against influenza vaccine (to test for responses against anticipated novel antigens in seronegative patients) and recall (tetanus toxoid [TT] booster dose) antigens. ⋯ This study provides Class I evidence that in some patients with MS receiving immunizations, concurrent fingolimod treatment in comparison to placebo decreases vaccination-induced immune responses.
-
Randomized Controlled Trial Multicenter Study
Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2.
To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH). ⋯ This study provides Class I evidence that the effect of intensive BP lowering on physical function is not influenced by baseline BP.
-
Randomized Controlled Trial
Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD.
To study whether 60-Hz stimulation, compared with routine 130 Hz, improves swallowing function and freezing of gait (FOG) in patients with Parkinson disease (PD) who undergo bilateral subthalamic nucleus (STN) deep brain stimulation (DBS). ⋯ This study provides Class IV evidence that for patients with PD who experience FOG, STN-DBS at 60 Hz decreases aspiration events observed during MBS compared with DBS at 130 Hz.