Neurology
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Randomized Controlled Trial
rTMS in fibromyalgia: a randomized trial evaluating QoL and its brain metabolic substrate.
This double-blind, randomized, placebo-controlled study investigated the impact of repetitive transcranial magnetic stimulation (rTMS) on quality of life (QoL) of patients with fibromyalgia, and its possible brain metabolic substrate. ⋯ This study provides Class II evidence that rTMS compared with sham rTMS improves QoL in patients with fibromyalgia.
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Randomized Controlled Trial
tDCS in patients with disorders of consciousness: sham-controlled randomized double-blind study.
We assessed the effects of left dorsolateral prefrontal cortex transcranial direct current stimulation (DLPF-tDCS) on Coma Recovery Scale-Revised (CRS-R) scores in severely brain-damaged patients with disorders of consciousness. ⋯ This study provides Class II evidence that short-duration tDCS of the left DLPF cortex transiently improves consciousness as measured by CRS-R assessment in patients with MCS.
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Randomized Controlled Trial Comparative Study
Randomized trial of IV valproate vs metoclopramide vs ketorolac for acute migraine.
We compared the efficacy of IV valproate with metoclopramide and with ketorolac in patients presenting to an emergency department (ED) with acute migraine. ⋯ This study provides Class I evidence that in ED patients with acute migraine, IV valproate is inferior to metoclopramide or ketorolac in improving headache outcomes.
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Randomized Controlled Trial Comparative Study
Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON) trial: main results.
To determine whether extracranial-intracranial (EC-IC) bypass can improve cognition over 2 years compared to best medical therapy alone in patients with symptomatic internal carotid artery (ICA) occlusion and increased oxygen extraction fraction (OEF) on PET. ⋯ This study provides Class II evidence that for patients with symptomatic ICA occlusion and increased OEF on PET, EC-IC bypass compared to no bypass does not improve cognitive function after 2 years.
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Randomized Controlled Trial Multicenter Study
ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection?
To assess whether adding clopidogrel to acetylsalicylic acid (ASA) has a long-term protective vascular effect in patients with lacunar stroke while taking ASA. ⋯ This study provides Class I evidence that for patients with recent lacunar stroke while taking ASA, adding clopidogrel as compared to continuing ASA alone does not reduce the risk of recurrent stroke.