Neurology
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Randomized Controlled Trial Multicenter Study
Motor cortex stimulation does not improve dystonia secondary to a focal basal ganglia lesion.
To assess the efficacy of epidural motor cortex stimulation (MCS) on dystonia, spasticity, pain, and quality of life in patients with dystonia secondary to a focal basal ganglia (BG) lesion. ⋯ This study provides Class I evidence that bipolar epidural MCS with the anode placed over the motor representation of the most affected limb failed to improve any clinical feature in dystonia secondary to a focal BG lesion.
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Randomized Controlled Trial Multicenter Study
Cluster RCT of case management on patients' quality of life and caregiver strain in ALS.
To study the effect of case management on quality of life, caregiver strain, and perceived quality of care (QOC) in patients with amyotrophic lateral sclerosis (ALS) and their caregivers. ⋯ This study provides Class III evidence that case management in addition to multidisciplinary ALS care does not significantly improve health-related quality of life of patients with ALS.
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Randomized Controlled Trial
Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease.
To determine whether oral quinacrine increases survival in sporadic Creutzfeldt-Jakob disease (sCJD). ⋯ This study provides Class I evidence that quinacrine does not improve survival for people with sCJD when given orally at a dose of 300 mg per day for 2 months.
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Randomized Controlled Trial
Central pain modulation after subthalamic nucleus stimulation: A crossover randomized trial.
To investigate the acute effect of subthalamic nuclei deep brain stimulation (STN-DBS) and levodopa on pain and tolerance thresholds in patients with Parkinson disease. We hypothesized that a modification of pain threshold after STN-DBS would suggest a central modification of pain perception, whereas the absence of pain threshold change after STN-DBS would correspond to a peripheral mechanism via a decrease of painful stimuli. ⋯ Clinical pain alleviation after STN-DBS cannot be considered merely as a consequence of motor complications improvement and could be attributable to a direct central modulation of pain perception, via increased mechanical pain and tolerance thresholds.
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Randomized Controlled Trial
Discontinuation of statin therapy associates with Parkinson disease: a population-based study.
To evaluate the effect of discontinuing statin therapy on incidence of Parkinson disease (PD) in statin users. ⋯ Continuation of lipophilic statin therapy was associated with a decreased incidence of PD as compared to discontinuation in statin users, especially in subgroups of women and elderly. Long-term follow-up study is needed to clarify the potential beneficial role of lipophilic statins in PD.