Neurology
-
Randomized Controlled Trial
Scrambler therapy improves pain in neuromyelitis optica: A randomized controlled trial.
To determine whether Scrambler therapy is an effective, acceptable, and feasible treatment of persistent central neuropathic pain in patients with neuromyelitis optica spectrum disorder (NMOSD) and to explore the effect of Scrambler therapy on co-occurring symptoms. ⋯ This study provides Class II evidence that Scrambler therapy significantly reduces pain in patients with NMOSD and persistent central neuropathic pain.
-
Randomized Controlled Trial Multicenter Study
Efficacy and safety of eptinezumab in patients with chronic migraine: PROMISE-2.
To evaluate the efficacy and safety of eptinezumab, a humanized anti-calcitonin gene-related peptide monoclonal antibody, in the preventive treatment of chronic migraine (CM). ⋯ NCT02974153.
-
Randomized Controlled Trial
Noninvasive vagus nerve stimulation and the trigeminal autonomic reflex: An fMRI study.
The trigeminal autonomic reflex is a physiologic reflex that plays a crucial role in primary headache and particularly in trigeminal autonomic cephalalgias, such as cluster headache. Previous studies have shown that this reflex can be modulated by the vagus nerve, leading to an inhibition of the parasympathetic output of the reflex in healthy participants. The aim of the present study was to characterize neural correlates of the modulatory effect of noninvasive vagus nerve stimulation (nVNS) on the trigeminal autonomic reflex. ⋯ These findings indicate a complex network involved in the modulatory effect of nVNS including the hypothalamus, the sTN, the pontine nucleus, and the parahippocampal gyrus.
-
Randomized Controlled Trial Multicenter Study Comparative Study
Anesthetic management during endovascular treatment of acute ischemic stroke in the MR CLEAN Registry.
To compare outcomes after endovascular treatment (EVT) for acute ischemic stroke with 3 different types of anesthetic management in clinical practice, as anesthetic management may influence functional outcome. ⋯ This study provides Class III evidence that for patients with acute ischemic stroke undergoing EVT, LA improves functional outcome compared to GA or CS.
-
Randomized Controlled Trial
Two randomized migraine studies of galcanezumab: Effects on patient functioning and disability.
To evaluate changes from baseline in patient-reported outcomes for measures of functioning and disability among patients with migraine treated with galcanezumab or placebo. ⋯ This study provides Class II evidence that for patients with migraine, galcanezumab (120 mg or 240 mg) given once monthly improved functioning and reduced disability.