Neurology
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Randomized Controlled Trial Multicenter Study Clinical Trial
Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD: a randomized trial.
To compare the efficacy of unilateral pallidotomy and bilateral subthalamic nucleus (STN) stimulation in patients with advanced Parkinson disease (PD) in a randomized, observer-blind, multicenter trial. ⋯ Bilateral STN stimulation is more effective than unilateral pallidotomy in reducing parkinsonian symptoms in patients with advanced PD.
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Randomized Controlled Trial Clinical Trial
Valproic acid has no effect on pain in polyneuropathy: a randomized, controlled trial.
The aim of this randomized, double-blind, placebo-controlled cross-over study was to test whether valproic acid relieves painful polyneuropathy. Thirty-one patients completed two treatment phases of 4 weeks' duration with valproic acid (1,500 mg daily) and placebo. There was no significant difference between valproic acid and placebo in the rating of total pain (median, 5 in the valproic acid period vs 6 in the placebo period; p = 0.24) or in individual pain ratings.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Gabapentin in the prophylaxis of chronic daily headache: a randomized, placebo-controlled study.
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Randomized Controlled Trial Clinical Trial
A randomized, double-blind, placebo controlled study on analgesic effects of botulinum toxin A.
Botulinum toxin type A (BTXA) is used to treat neurologic disorders associated with increased muscle tone. Its use is often associated with pain relief. ⋯ The results suggest that pain reduction after BTXA treatment is mediated through its effect on muscle tone rather than a direct analgesic effect.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Donepezil in vascular dementia: a randomized, placebo-controlled study.
To evaluate the efficacy and tolerability of donepezil in patients with vascular dementia (VaD). ⋯ Donepezil-treated patients demonstrated significant improvements in cognition and global function compared with placebo-treated patients, and donepezil was well tolerated.