Neurology
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Randomized Controlled Trial Multicenter Study Clinical Trial
Gabapentin in the prophylaxis of chronic daily headache: a randomized, placebo-controlled study.
To compare efficacy and safety of gabapentin (GPT) versus placebo for prophylaxis of chronic daily headache (CDH) (headache at least 15 days/month of greater than 4 hours duration over preceding 6 months). ⋯ Gabapentin represents a therapeutic option for chronic daily headache.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Donepezil in vascular dementia: a randomized, placebo-controlled study.
To evaluate the efficacy and tolerability of donepezil in patients with vascular dementia (VaD). ⋯ Donepezil-treated patients demonstrated significant improvements in cognition and global function compared with placebo-treated patients, and donepezil was well tolerated.
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Randomized Controlled Trial Multicenter Study Clinical Trial
A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis.
To determine if long-term topiramate therapy is safe and slows disease progression in patients with ALS. ⋯ At the dose studied, topiramate did not have a beneficial effect for patients with ALS. High-dose topiramate treatment was associated with a faster rate of decline in muscle strength as measured by MVIC and with an increased risk for several adverse events in patients with ALS. Given the lack of efficacy and large number of adverse effects, further studies of topiramate at a dose of 800 mg or maximum tolerated dose up to 800 mg/day are not warranted.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures.
Pregabalin is an alpha(2)-delta ligand that has anxiolytic, analgesic, and anticonvulsant properties. ⋯ Adjunctive therapy with pregabalin 150, 300, and 600 mg/d, given in twice-daily doses without titration, is significantly effective and well tolerated in the treatment of patients with partial seizures as demonstrated in patients with refractory partial seizures.
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Multicenter Study
Spinal manipulative therapy is an independent risk factor for vertebral artery dissection.
To determine whether spinal manipulative therapy (SMT) is an independent risk factor for cervical artery dissection. ⋯ This case-controlled study of the influence of SMT and cervical arterial dissection shows that SMT is independently associated with vertebral arterial dissection, even after controlling for neck pain. Patients undergoing SMT should be consented for risk of stroke or vascular injury from the procedure. A significant increase in neck pain following spinal manipulative therapy warrants immediate medical evaluation.