Neurology
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Randomized Controlled Trial Multicenter Study Clinical Trial
A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis.
To determine if long-term topiramate therapy is safe and slows disease progression in patients with ALS. ⋯ At the dose studied, topiramate did not have a beneficial effect for patients with ALS. High-dose topiramate treatment was associated with a faster rate of decline in muscle strength as measured by MVIC and with an increased risk for several adverse events in patients with ALS. Given the lack of efficacy and large number of adverse effects, further studies of topiramate at a dose of 800 mg or maximum tolerated dose up to 800 mg/day are not warranted.
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Randomized Controlled Trial Clinical Trial Retracted Publication
Amelioration of osteoporosis and hypovitaminosis D by sunlight exposure in stroke patients.
The authors' previous investigations have disclosed low serum 25-hydroxyvitamin D (25-OHD) concentrations in 45 patients during long-term hospitalization following stroke (mean 5.9 ng/mL). This 25-OHD deficiency resulted from sunlight deprivation. ⋯ Sunlight exposure can increase the BMD of vitamin D-deficient bone by increasing 25-OHD concentration.
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Comment Letter Randomized Controlled Trial Clinical Trial
Randomized clinical trial of magnesium, diazepam, or both after out-of-hospital cardiac arrest.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures.
Pregabalin is an alpha(2)-delta ligand that has anxiolytic, analgesic, and anticonvulsant properties. ⋯ Adjunctive therapy with pregabalin 150, 300, and 600 mg/d, given in twice-daily doses without titration, is significantly effective and well tolerated in the treatment of patients with partial seizures as demonstrated in patients with refractory partial seizures.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trial.
To evaluate the efficacy and tolerability of lamotrigine (LTG) for the treatment of pain in HIV-associated sensory neuropathies. ⋯ Lamotrigine was well-tolerated and effective for HIV-associated neuropathic pain in patients receiving neurotoxic antiretroviral therapy. Additional research is warranted to understand the differing response among patients receiving neurotoxic antiretroviral therapy compared with those not receiving neurotoxic antiretroviral therapy.