Neurology
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial.
To evaluate the efficacy and safety of 500 mg bid and 1500 mg bid levetiracetam as adjunctive therapy for refractory partial seizures in a double-blind, randomized, placebo-controlled, parallel-group, multicenter trial. ⋯ Adjunctive therapy with levetiracetam was effective and well tolerated in controlling partial seizures.
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Randomized Controlled Trial Multicenter Study Clinical Trial
A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathy.
To investigate the analgesic efficacy of lamotrigine in the treatment of painful HIV-associated distal sensory polyneuropathy (DSP). ⋯ In this small trial, lamotrigine showed promise in the treatment of pain associated with HIV-related DSP. The frequency of rash was greater than in lamotrigine studies in epilepsy. A larger controlled study of lamotrigine is warranted.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Oral zolmitriptan is effective in the acute treatment of cluster headache.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Antifibrinolytic treatment in subarachnoid hemorrhage: a randomized placebo-controlled trial. STAR Study Group.
To investigate whether antifibrinolytics in combination with treatment to prevent cerebral ischemia improve outcome in patients with subarachnoid hemorrhage (SAH) in whom occlusion of the aneurysm is delayed. ⋯ Antifibrinolytic treatment combined with treatment to prevent cerebral ischemia does not improve outcome.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-responsive cervical dystonia.
To determine the safety and efficacy of botulinum toxin type B (BoNT/B) in patients with cervical dystonia (CD). ⋯ Botulinum toxin type B (NeuroBloc) is safe and efficacious at 5,000 U and 10,000 U for the management of patients with cervical dystonia.