Neurology
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Randomized Controlled Trial Clinical Trial
Verapamil in the prophylaxis of episodic cluster headache: a double-blind study versus placebo.
The authors performed a double-blind, double-dummy study to compare the efficacy of verapamil with placebo in the prophylaxis of episodic cluster headache. After 5 days' run-in, 15 patients received verapamil (120 mg tid) and 15 received placebo (tid) for 14 days. ⋯ Side effects were mild. These findings provide objective evidence for the effectiveness of verapamil in episodic cluster headache prophylaxis.
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Randomized Controlled Trial Clinical Trial
A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291.
To evaluate the safety and efficacy of recombinant human nerve growth factor (rhNGF) in HIV-associated sensory neuropathy (SN) within a multicenter, placebo-controlled, randomized trial (ACTG 291). ⋯ We found a positive effect of recombinant human nerve growth factor on neuropathic pain and pin sensitivity in HIV-associated sensory neuropathy. rhNGF was safe and well tolerated, but injection site pain was frequent.
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Randomized Controlled Trial Clinical Trial
Randomized pilot trial of postoperative aspirin in subarachnoid hemorrhage.
To assess the safety and feasibility of a clinical trial on the effectiveness of acetylsalicylic acid (ASA) in subarachnoid hemorrhage (SAH). ⋯ This pilot study shows that a clinical trial of acetylsalicylic acid (ASA) in subarachnoid hemorrhage (SAH) is feasible and probably safe. The effectiveness of ASA on functional outcome and delayed cerebral ischemia has to be studied in a larger trial.
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Randomized Controlled Trial Clinical Trial
Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study.
To investigate the effects of systemic administration of lidocaine on different components of neuropathic central pains by quantitative sensory testing. ⋯ Systemic lidocaine can induce a significant and selective reduction of several components of pain caused by CNS injuries. The observed preferential antihyperalgesic and antiallodynic effects of this drug suggest a selective central action on the mechanisms underlying these evoked pains.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Antifibrinolytic treatment in subarachnoid hemorrhage: a randomized placebo-controlled trial. STAR Study Group.
To investigate whether antifibrinolytics in combination with treatment to prevent cerebral ischemia improve outcome in patients with subarachnoid hemorrhage (SAH) in whom occlusion of the aneurysm is delayed. ⋯ Antifibrinolytic treatment combined with treatment to prevent cerebral ischemia does not improve outcome.