Neurology
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Randomized Controlled Trial
Nonpainful remote electrical stimulation alleviates episodic migraine pain.
To evaluate the efficacy of remote nonpainful electrical upper arm skin stimulation in reducing migraine attack pain. ⋯ This study provides Class III evidence that for patients with an acute migraine headache, remote nonpainful electrical stimulation on the upper arm skin reduces migraine pain.
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Randomized Controlled Trial
Methylphenidate, cognition, and epilepsy: A double-blind, placebo-controlled, single-dose study.
To evaluate the potential efficacy of immediate-release methylphenidate (MPH) for treating cognitive deficits in epilepsy. ⋯ This study provides Class II evidence that single doses of MPH improve cognitive performance on some measures of attention and processing speed in patients with epilepsy and cognitive complaints.
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Randomized Controlled Trial Multicenter Study
Endovascular treatment improves cognition after stroke: A secondary analysis of REVASCAT trial.
To investigate the effect of endovascular treatment on cognitive function as a prespecified secondary analysis of the REVASCAT (Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours) trial. ⋯ This study provides Class I evidence that for patients with stroke from acute anterior circulation proximal arterial occlusion, thrombectomy improves performance on the TMT at 3 months.
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Randomized Controlled Trial
Multifocal repetitive TMS for motor and mood symptoms of Parkinson disease: A randomized trial.
To assess whether multifocal, high-frequency repetitive transcranial magnetic stimulation (rTMS) of motor and prefrontal cortex benefits motor and mood symptoms in patients with Parkinson disease (PD). ⋯ This study provides Class I evidence that in patients with PD with depression, M1 rTMS leads to improvement in motor function while DLPFC rTMS does not lead to improvement in depression compared to sham rTMS.
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Randomized Controlled Trial Multicenter Study Comparative Study
Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes.
To evaluate the comparative safety and adjunctive efficacy of pregabalin and gabapentin in reducing seizure frequency in patients with partial-onset seizures based on prestudy modeling showing superior efficacy for pregabalin. ⋯ This study provides Class II evidence that for patients with partial seizures enrolled in this study, pregabalin is not superior to gabapentin in reducing seizure frequency. Because of the atypical response rates, the results of this study are poorly generalizable to other epilepsy populations.