Neurology
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Randomized Controlled Trial
Mind-body therapy via videoconferencing in patients with neurofibromatosis: An RCT.
To test, within a single-blind randomized controlled trial, the feasibility, acceptability, efficacy, and durability of a mind-body program (the Relaxation Response Resiliency Program for neurofibromatosis [3RP-NF]) vs an attention placebo control (Health Enhancement Program for NF [HEP-NF]), both delivered via group videoconferencing. ⋯ This study provides Class II evidence that for patients with NF, a mind-body program is superior to an attention placebo control in improving QoL.
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Randomized Controlled Trial Multicenter Study
Chronic migraine headache prevention with noninvasive vagus nerve stimulation: The EVENT study.
To evaluate the feasibility, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS) for the prevention of chronic migraine (CM) attacks. ⋯ This study provides Class II evidence that for patients with CM, nVNS is safe, is well-tolerated, and did not significantly change the number of headache days. This pilot study lacked the precision to exclude important safety issues or benefits of nVNS.
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Randomized Controlled Trial
Standardized EEG interpretation accurately predicts prognosis after cardiac arrest.
To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by the American Clinical Neurophysiology Society. ⋯ Highly malignant EEG after rewarming reliably predicted poor outcome in half of patients without false predictions. An isolated finding of a single malignant feature did not predict poor outcome whereas a benign EEG was highly predictive of a good outcome.
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Randomized Controlled Trial Multicenter Study
Cost-effectiveness of endovascular thrombectomy in patients with acute ischemic stroke.
To evaluate the cost-effectiveness of adding endovascular thrombectomy to standard care in patients with acute ischemic stroke. ⋯ Adding endovascular treatment to standard care resulted in substantial clinical benefits at low costs. The results were consistent throughout irrespective of whether data from ESCAPE, EXTEND-IA, MR CLEAN, REVASCAT, or SWIFT PRIME were used in this model.
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Randomized Controlled Trial Comparative Study
Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke: CHANCE substudy.
We compared the effect of clopidogrel plus aspirin vs aspirin alone on functional outcome and quality of life in the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial of aspirin-clopidogrel vs aspirin alone after acute minor stroke or TIA. ⋯ This study provides Class II evidence that for patients with acute minor stroke or TIA, clopidogrel plus aspirin compared to aspirin alone improves 90-day functional outcome (absolute reduction of poor outcome 1.70%, 95% confidence interval 0.03%-3.42%).