Respiratory care
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Randomized Controlled Trial Multicenter Study
Tobramycin Inhalation Powder in Cystic Fibrosis Patients: Response by Age Group.
Tobramycin powder for inhalation (TIP) is a drug-device combination designed to reduce treatment time and improve ease of use compared with tobramycin inhalation solution (TIS) in cystic fibrosis (CF) patients. However, the ability of patients to use dry powder inhalers, and the efficacy of the treatments, may vary by age. ⋯ TIP is comparable to TIS in efficacy outcomes and safety profile but had greater patient satisfaction in all the age groups.
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Randomized Controlled Trial Comparative Study
Comparison of distinct incentive spirometers on chest wall volumes, inspiratory muscular activity and thoracoabdominal synchrony in the elderly.
Aging causes physiological and functional changes that impair pulmonary function. Incentive spirometry is widely used for lung expansion, but the effects of volume-oriented incentive spirometry (VIS) versus flow-oriented incentive spirometry (FIS) on chest wall volumes, inspiratory muscle activity, and thoracoabdominal synchrony in the elderly are poorly understood. We compared VIS and FIS in elderly subjects and healthy adult subjects. ⋯ Incentive spirometry performance is influenced by age, and the differences between elderly and healthy adults response should be considered in clinical practice.
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Randomized Controlled Trial
Randomized controlled trial of exercise training in chronic respiratory failure due to kyphoscoliosis.
Research has provided evidence for the safety, feasibility, and efficacy of exercise training in patients with COPD. However, little is known about the impact of exercise training in patients with chronic respiratory failure due to kyphoscoliosis. We evaluated the effect of an exercise training program on exercise capacity, muscle strength, dyspnea, and quality-of-life indices in subjects with chronic respiratory failure due to kyphoscoliosis. ⋯ In patients with chronic respiratory failure due to kyphoscoliosis, exercise training improved exercise capacity, peripheral muscle strength, dyspnea, and quality of life. (Deutschen Register Klinischer Studien DRKS00000443).
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Randomized Controlled Trial
SCINTIGRAPHIC ASSESSMENT OF RADIOAEROSOL PULMONARY DEPOSITION THROUGH ACAPELLA DEVICE WITH DIFFERENT NEBULISER CONFIGURATIONS.
The Acapella device produces high-frequency oscillations and positive expiratory pressure to promote bronchial secretion clearance. Its performance during aerosol delivery has not been described. We evaluated the effect of nebulizer and Acapella configuration on pulmonary deposition of radio-tagged aerosol in healthy subjects. ⋯ Placing the nebulizer distal to the Acapella, as recommended by the manufacturer, decreased intrapulmonary deposition, compared to placing the nebulizer between the Acapella and the patient airway, or delivering aerosol without the Acapella in the circuit. (ClinicalTrials.gov NCT01102166).