Respiratory care
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Randomized Controlled Trial Multicenter Study
Identifying Cancer Patients With Acute Respiratory Failure at High Risk for Intubation and Mechanical Ventilation.
We sought to identify risk factors for mechanical ventilation in patients with malignancies and acute respiratory failure (ARF). ⋯ In cancer patients with ARF, hypoxemia, extent of pulmonary infiltration on chest x-ray, or hemodynamic dysfunction are risk factors for invasive mechanical ventilation. Mortality was not significantly different between NIV failure and first-line intubation.
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Multicenter Study
Inhaled Corticosteroids Do Not Influence the Early Inflammatory Response and Clinical Presentation of Hospitalized Subjects With COPD Exacerbation.
Inhaled corticosteroids are anti-inflammatory medications that can down-regulate the immunologic response in patients with COPD; however, their role at onset of COPD exacerbation is still not understood. The aim of this study was to assess the early inflammatory response and clinical presentation of patients with COPD exacerbation mediated by inhaled corticosteroids. ⋯ Our study demonstrates a lack of inhaled corticosteroid influence in the early systemic inflammatory response to and clinical presentation of COPD exacerbation.
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Randomized Controlled Trial Multicenter Study
Guaifenesin has no effect on sputum volume or sputum properties in adolescents and adults with an acute respiratory tract infection.
Guaifenesin (glyceryl guaiacolate ether [GGE]) has been studied as a cough suppressant and as an expectorant; however, published studies to date have failed to find a consistent benefit. ⋯ The recommended dose of GGE had no measurable effect on sputum volume or properties and is unlikely to be an expectorant or mucolytic when used to treat acute RTI. (ClinicalTrials.gov registration NCT01046136.).
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Randomized Controlled Trial Multicenter Study
Tobramycin Inhalation Powder in Cystic Fibrosis Patients: Response by Age Group.
Tobramycin powder for inhalation (TIP) is a drug-device combination designed to reduce treatment time and improve ease of use compared with tobramycin inhalation solution (TIS) in cystic fibrosis (CF) patients. However, the ability of patients to use dry powder inhalers, and the efficacy of the treatments, may vary by age. ⋯ TIP is comparable to TIS in efficacy outcomes and safety profile but had greater patient satisfaction in all the age groups.
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Multicenter Study Observational Study
Importance of inhaler device use status in the control of asthma in adults: ASIT (Asthma Inhaler Treatment) Study.
Proper education and training in correct inhalation technique has been reported to have a substantial role in the achievement of optimal therapeutic benefit and asthma control. The present study was designed to evaluate inhaler technique and the role of education in relation to asthma control among patients with persistent asthma in Turkey. ⋯ Close follow-up with repeated checking of the patient's inhaler technique and correction of errors each time by a physician seem to be associated with a significant decrease in the percent of patients who make basic errors in inhalation maneuvers and device-independent errors, and with better control of persistent asthma.