European journal of trauma and emergency surgery : official publication of the European Trauma Society
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Eur J Trauma Emerg Surg · Aug 2016
Randomized Controlled TrialThe role of pharmacological steroid therapy in preservation of renal function in severely injured patients requiring massive transfusion.
Glucocorticoids (GC) attenuate the post-insult inflammatory response and have been observed to confer end-organ protection following a variety of ischemic insults. We aim to assess this benefit on renal perfusion and function in injured patients requiring massive transfusion. ⋯ In the absence of larger studies, this study demonstrates that GC likely have no role in preserving renal function in severely injured patients.