BMJ open

The most recent articles from: BMJ Open August 2020

BMJ open · Aug 2020

Meta Analysis

What is the optimum systemic treatment for advanced/metastatic renal cell carcinoma of favourable, intermediate and poor risk, respectively? A systematic review and network meta-analysis.

The optimum systemic therapies for advanced/metastatic renal cell carcinoma (RCC) of favourable, intermediate and poor risk have not been established. We aimed to compare and rank the effects associated with systemic therapies in the first-line setting. ⋯ Avelumab plus axitinib might be the optimum treatment for advanced/metastatic RCC of favourable risk. Pembrolizumab plus axitinib might be the optimum treatment for intermediate-risk and poor-risk patients.

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BMJ open · Aug 2020

Meta Analysis

Risk factors for pain and functional impairment in people with knee and hip osteoarthritis: a systematic review and meta-analysis.

To identify risk factors for pain and functional deterioration in people with knee and hip osteoarthritis (OA) to form the basis of a future 'stratification tool' for OA development or progression. ⋯ CRD42018117643.

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