Anesthesia progress
-
Anesthesia progress · Jan 2002
Review Case ReportsParadoxical reactions to benzodiazepines in intravenous sedation: a report of 2 cases and review of the literature.
Paradoxical reactions to benzodiazepines have been thoroughly reported since the introduction of this type of drug. The mechanism of benzodiazepine action is through the gamma-aminobutyric acid receptors. ⋯ Two cases of paradoxical reactions associated with the use of intravenous midazolam are presented, and the management of this complication and its different etiologies are reviewed. The relationship of the paradoxical reaction to alteration of the cholinergic homeostasis, serotonin levels, the role of genetics, and gamma-aminobutyric acid receptor configuration is discussed.