Masui. The Japanese journal of anesthesiology
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Randomized Controlled Trial Clinical Trial
[The effects of hypertonic lactated Ringer's solution during transurethral surgery].
We studied the plasma sodium level and osmolarity when hypertonic lactated Ringer's solution (HLS) with sodium of 213 mEq.l-1 was infused as intraoperative fluid in patients (n = 7) undergoing transurethral resection of the prostate (TUR-P). Regular lactated Ringer's solution was infused in other patients (n = 7) as the control drug. Plasma sodium level and plasma osmolarity decreased significantly in the patients with regular lactated Ringer's solution group. ⋯ However, three hours after the administration, serum ADH level increased significantly in HLS group while it remained unchanged in control group. It was suspected that the increase in serum sodium concentration might have stimulated secretion of ADH after TUR-P. Our study suggests that the administration of HLS prevents the hyponatremia and hypoosmolarity in patients undergoing TUR-P and that the HLS could be used routinely during this procedure as the essential fluid therapy.
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Randomized Controlled Trial Clinical Trial
[The arterial blood gas change in anesthetized patients with apnea: disadvantage of hyperventilation before intubation].
We studied the arterial blood gas changes during 4 minute apnea period without using constant oxygen flow under anesthesia. Fifteen adult surgical patients (ASA PS 1 or 2, 21-49 years of age) were randomly divided into 3 groups by ETCO2 before the start of apnea (group I: 40 mmHg, group II: 30 mmHg, group III: 20 mmHg). In addition, each patient was monitored with pulse oximetry, ECG, blood pressure, FIO2 and ETCO2. ⋯ In conclusion, the rate of rise of PaCO2 in anesthetized patients with apnea was logarithmic and there was no correlation with pre-apnea ETCO2. The rate of SpO2 decrease was significant in hyperventilated group (III). Thus, hyperventilation applied before the endotracheal intubation is not of benefit to the oxygenation of healthy humans.