Masui. The Japanese journal of anesthesiology
-
Comparative Study
[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine].
The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement. ⋯ The incidence of PONV in propofol-anesthetized patients receiving pentazocine as opioid supplement is not different from that in patients receiving fentanyl.
-
Remifentanil is bound strongly to the mu-opioid receptor and less to the delta - and kappa -receptors. It has pharmacodynamic properties like those of fentanyl and its derivatives. Remifentanil is not bound significantly to any other non-opioid receptors and is competitively antagonized by naloxone. ⋯ These characteristics must be very convenient for the anesthesia technique of ambulatory surgery. However, on the opposite side, we should consider the management of postoperative pain for the patient after the remifentanil anesthesia. These topics on the characteristics of remifentanil and its future are discussed by the experts among Japanese anesthesiologists.
-
Review Comparative Study
[Pharmacodynamics and pharmacokinetics of remifentanil: overview and comparison with other opioids].
In this review, the authors tried to summarize the characteristics and main differences of remifentanil with other opioids, and to overview its pharmacodynamics and pharmacokinetics. Clearance and volume of distribution of remifentnail are extremely different from other conventional opioids. ⋯ As remifentanil is metabolized by a non-specific esterase, excretion of remifentnil is predictable in basically all patients undergoing general anesthesia and surgery. Therefore, remifentanil is considered to be an optimal opioid as an analgesic combined either with inhalational anesthetics or intravenous hypnotics in balanced general anesthesia.
-
Review Case Reports
[Clinical electroencephalographic monitoring of depth of anesthesia].