Masui. The Japanese journal of anesthesiology
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Randomized Controlled Trial
[Balanced anesthesia with continuous ketamine reduces adverse effects of remifentanil].
We evaluated the use of continuous infusion of ketamine to reduce intraoperative remifentanil side effects, such as bradycardia and hypotension, and to improve postoperative analgesia from balanced anesthesia with remifentanil. ⋯ Remifentanil-based anesthesia with continuous ketamine decreases intraoperative side effects and postoperative NSAIDs request. Thus, intraoperative continuous ketamine may be a useful adjuvant to remifentanil.
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Comparative Study Clinical Trial
[Comparative study of sublingual midazolam with oral midazolam for premedication in pediatric anesthesia].
We studied the efficacy of sublingual midazolam compared with oral midazolam for predmedication in children. ⋯ Sublingual midazolam 0.2 mg x kg(-1) is useful for premedication in pediatric anesthesia, and it equals with oral midazolam 0.5 mg x kg(-1) in efficacy.
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Randomized Controlled Trial
[Exposure to nitrous oxide may increase airway inflammation during sevoflurane anesthesia].
The purpose of this study was to examine whether nitrous oxide increases the inflammatory reaction in the airway in patients undergoing minor surgery. ⋯ The pulmonary immunologic function changed progressively during anesthesia, surgery and positive pressure mechanical ventilation. The data from this study suggest that the immune ability of the lung may possibly change due to the administration of nitrous oxide. As a result, our findings suggest that the postoperative inflammatory reaction in the lung may increase when sevoflurane plus nitrous oxide are used during general anesthesia.
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Case Reports
[Awake intubation using lightwand technique under conscious sedation with remifentanil].
We experienced two cases of difficult airway due to deformities in the oral cavities. The first patient was a 62-year-old woman with a large benign soft palate tumor and the second was a 64-year-old woman with macroglossia secondary to acromegaly. Both patients were evaluated difficult to ventilate via face mask and presenting serious risks for tracheal intubation under general anesthesia. ⋯ Tracheal intubation was managed successfully in both cases and the operations were completed under general anesthesia. Although the patients were aware of being intubated, they could not recall the procedures postoperatively. The awake intubation technique using the lightwand under conscious sedation with remifentanil can be safely applied to a patient with difficult airway.
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Case Reports
[Case of transfusion-related acute lung injury associated with severe intraoperative hypoxemia].
A 39-year-old woman, undergoing debridement and flap reconstruction for a soft tissue infection in an upper limb, developed transfusion-related acute lung injury (TRALI) and hypoxemia after an intraoperative transfusion. Perioperatively, she received 8 units of packed red blood cells (RBCs) and 5 units of fresh frozen plasma. Shortly thereafter, hemoglobin oxygen saturation decreased from 100% to 94%, as measured with a pulse oximeter. ⋯ Pulmonary edema improved and the trachea was extubated 34 hours after surgery. Antibodies against HLA were detected in the RBC donor serum sample, and a crossmatch test between the patient lymphocytes and donor serum was positive. We concluded that perioperative transfusion of blood components has a potential to provoke serious TRALI.